On Sept. 17, 2017, the Frick lab and friends participated in our first ever Walk to End Alzheimer’s. The Milwaukee walk is the 10th largest in the country, and passes through the scenic Lakeshore State Park on the Milwaukee Harbor. Our team, called Arlene’s Alzheimer’s Army, walked to support research, caregivers, and patients, including Dr. Frick’s Aunt Arlene, who is valiantly battling late-stage Alzheimer’s.
Jaekyoon Kim, a senior graduate student in the lab, is the first author on a recently published paper in Psychoneuroendocrinology entitled, “Distinct effects of estrogen receptor antagonism on object recognition and spatial memory consolidation in ovariectomized mice”. Jaekyoon’s studies indicate that ERα antagonism impairs spatial, but not object recognition, memory consolidation in ovariectomized mice, whereas ERβ antagonism impairs both types of memory at the doses tested. These data suggest that ERα and ERβ are necessary for OP memory consolidation, but that only ERβ is necessary for OR memory consolidation, in ovariectomized mice. A PDF of this paper can be downloaded from the Publications page on this website. Congratulations Jaekyoon!
On August 29, grad student Jennifer Tuscher successfully defended her doctoral dissertation entitled, “The role of the hippocampus and prefrontal cortex in the estrogenic regulation of memory”. Congratulations Dr. Jen!
Dr. Frick’s NIH-funded grant to study cell-signaling and growth factor mechanisms underlying estradiol’s beneficial effects on memory formation was recently profiled as one of the top 6 NIH-funded research projects at UWM.
See the article at: http://uwm.edu/news/top-6-nih-funded-research-projects-uwm/.
Second year graduate student Lisa Taxier authored a new paper based on her undergraduate senior thesis research at Carleton College. The paper, published in Physiology and Behavior, studied the effects pubertal ovarian hormones on paced mating and conditioned place preference in female rats. The work showed that female rats lacking exposure to pubertal ovarian hormones show altered activity and withdrawal behavior during paced mating, but retain the ability to show a preference for a sexual partner and to acquire a conditioned place preference for paced mating. Congratulations Lisa!
Milwaukee Public Television will be screening the new Alzheimer’s documentary, “Alzheimer’s: Every Minute Counts” on Jan. 4, 2017 at Discovery World. The screening will begin at 7 pm, followed by a panel discussion with numerous community members including Dr. Frick. See MPTV’s press release for more information on the event: http://www.mptv.org/news/press/release/?n_id=1127
Postdoc Wendy Koss was awarded a Taconic Biosciences Travel Award for her poster presentation entitled, “Memory-enhancing effects of 17β-estradiol in male and female mice”, at the 2016 Society for Neuroscience meeting in November. Congratulations Wendy!
Jen Tuscher has been awarded the 2016-2017 Ruth G. and Joseph D. Matarazzo Scholarship from the American Psychological Foundation (APF) and Council of Graduate Departments of Psychology (COGDOP). This highly competitive scholarship provides Jen research funds to conduct her dissertation. Congratulations Jen!
Dr. Frick has been awarded a 5-year R01 grant by the National Institute of Mental Health. The grant is entitled, Mechanisms underlying memory regulation of 17beta-estradiol, canonical Wnt signaling, and BDNF in male and female mice. The goal of this project is to determine the extent to which canonical Wnt signaling and BDNF contribute to the memory enhancing effects of estradiol in female and male mice.
Dr. Frick has been awarded one of nine inaugural Sex and Gender in Alzheimer’s (SAGA) research grants from the Alzheimer’s Association. The 3-year project entitled, Estradiol-APOE interactions in a mouse model of AD, will study how genetic risk factors interact with sex and estrogen treatment to regulate memory and brain function in a mouse model of Alzheimer’s disease.