The Frick lab walks for Alzheimer’s Disease

On Sept. 17, 2017, the Frick lab and friends participated in our first ever Walk to End Alzheimer’s.  The Milwaukee walk is the 10th largest in the country, and passes through the scenic Lakeshore State Park on the Milwaukee Harbor.  Our team, called Arlene’s Alzheimer’s Army, walked to support research, caregivers, and patients, including Dr. Frick’s Aunt Arlene, who is valiantly battling late-stage Alzheimer’s.

Jaekyoon Kim publishes new paper

Jaekyoon Kim, a senior graduate student in the lab, is the first author on a recently published paper in Psychoneuroendocrinology entitled, “Distinct effects of estrogen receptor antagonism on object recognition and spatial memory consolidation in ovariectomized mice”.  Jaekyoon’s studies indicate that ERα antagonism impairs spatial, but not object recognition, memory consolidation in ovariectomized mice, whereas ERβ antagonism impairs both types of memory at the doses tested. These data suggest that ERα and ERβ are necessary for OP memory consolidation, but that only ERβ is necessary for OR memory consolidation, in ovariectomized mice.  A PDF of this paper can be downloaded from the Publications page on this website.  Congratulations Jaekyoon!

Lisa Taxier’s Undergraduate thesis research published

Second year graduate student Lisa Taxier authored a new paper based on her undergraduate senior thesis research at Carleton College.  The paper, published in Physiology and Behavior, studied the effects pubertal ovarian hormones on paced mating and conditioned place preference in female rats.  The work showed that female rats lacking exposure to pubertal ovarian hormones show altered activity and withdrawal behavior during paced mating, but retain the ability to show a preference for a sexual partner and to acquire a conditioned place preference for paced mating.  Congratulations Lisa!

Dr. Frick to be a panelist for screening of new Alzheimer’s documentary on Jan. 4, 2017

Milwaukee Public Television will be screening the new Alzheimer’s documentary, “Alzheimer’s: Every Minute Counts” on Jan. 4, 2017 at Discovery World.  The screening will begin at 7 pm, followed by a panel discussion with numerous community members including Dr. Frick.  See MPTV’s press release for more information on the event:

Dr. Frick awarded an R01 grant by the NIMH

720px-us-nih-nimh-logo-svgDr. Frick has been awarded a 5-year R01 grant by the National Institute of Mental Health.  The grant is entitled, Mechanisms underlying memory regulation of 17beta-estradiol, canonical Wnt signaling, and BDNF in male and female mice.  The goal of this project is to determine the extent to which canonical Wnt signaling and BDNF contribute to the memory enhancing effects of estradiol in female and male mice.