Useful Resources for Organic Chemists

Tips & Tricks for Organic Chemists (Not Voodoo X) SynArchive: A total synthesis database Chem-Station Chemistry By Design  Total Syntheses by Reich at Madison pKa Tables (Bordwell, Evans) LC/MS Adducts and Clusters Organic Chemistry Portal ReactionFlash App by Reaxys (Android,… Read More

Recent Publications

2016

443. “Antagonism of Triazolam Self-Administration in Rhesus Monkeys Responding Under a Progressive-ratio Schedule: In vivo Apparent pA2 Analysis,” Fischer, B; Platt, D.; Rallapalli, S.; Namjoshi, O.; Cook, J.; Rowlett, J.; Drug and Alcohol Dependence, 158, 22-29 (2016).
444. “eEF2 Pathway Controls Dentrate Gyrus Dependent Behaviour and Excitation-inhibition Balance,” Heise, C.; Taha, E.; Murru, L.; Ponzoni, L.; Cattaneo, A.; Guarnieri, F.C.; Montani, C.; Mossa, A.; Vezzoli, E.; Ippoliot, G.; Zapata, J.; Berrera, I.; Ryazanov, A.G.; Benfante, R.; Braida, D.; Francolinin, M.; Proud, Poe, M.M.; Stephen, M.; Cook, J.M.; C.; Valtorta, F.; Passafaro, M.; Sala, M.; Bachi, A.; Verpelli, C.; Rosenblum, K.; Sala, C.; Plus One, 00, 0000-0000 (2016).

445. “First in Vivo Testing of Novel Compounds Targeting Group 3 Medulloblastomas Using an Implantable Microdevice as a New Paradigm for Drug Development,” Jonas, O.; Calligaris, D.; Methuku, K.; Poe, M.M,; Tranghese, F.; Changelian, A.; Francois, J.; Sieghart, W.; Ernst, M.; Krummel, D.; Cook, J.M.; Pomeroy, S.; Cima, M.; Agar, N.; Langer, R.; Sengupta, S.; J. of Biomedical Nanotechnology, 12, 1297-1302 (2016).
446. “Modern Methods for the Total Synthesis of Important Oxindole Alkaloids.” Fonseca, G.; Cook, J.M.; Organic Chemistry Insights, 00, 0000-0000 (2016), in press.
447. “Sarpagine and Related Alkaloids,” O. Namjoshi; J.M. Cook, in “The Alkaloids,” Volume 76, Hans-Joachim Knölker, Editor, Elsevier, N.Y. pp. 64-171 (2016).
448. “Synthesis and Evaluation of Vitamin D Receptors-mediated Activities of Cholesterol and Vitamin D Metabolites,” Teske, K.; Bogart, J.; Sanchez, L.; Yu, O.; Preston, J.; Cook, J.; Silvaggi, N.; Bikle, D.; Arnold, L.; Eur. J. Med. Chem, 109, 238-246 (2016).
449. “Development of GABAA Receptor Subtype-Selective Imidazobenzodiazepines as Novel Asthma Treatments”, Forkuo, G.S.; Guthrie, M.; Yuan, N; Nieman, A.; Kodali, R; Jahan, R; Yocum, G.; Treven, M.; Stephen, M.; Poe, M.; Li, G.; Yu, O.; Hartzler, B.; Zahn, N.; Ernst, M.; Emala,C.; Stafford, D.; Cook, J.M.; Arnold, L.A., Molecular Pharmaceutics, (ACS), DOI: 10.1021/acs.molpharmaceut.6600159.
450. “ Identification of a Novel, Fast Acting GABAergic Antidepressent”, McMurray, K.; Ramakes, M.; Sidhu, P.; Elkin, P.; Cook, J.M.; Rawal, V.; Arnold,L.A.; Methuku, K.; Dulawa, S.;Palmer,A.; Nature Nerosci, submitted 0000-0000 (2016).
451. “Neonatal Bladder Inflammation Induces Long-term Visceral Pain and Altered Responses of Spinal Neurons in Adult Rats”, Kannampalli, P.; Babygirija,R.’ Zhang,J.; Poe,M.; Li,G.; Cook, J.M.; Shaker,R.; Banerjee, B.; Sengupta, J.; Submitted (2016).
452. “Modern Methods for Total Synthesis of Important Oxindole Alkaloids”, Fonseca, G.; Cook, J.M.; Organic Chemistry Insights 2016: 6 1-55 DOI: 10.4137/OCI.S17958.
453. “Early Life Stress is a Risk Factor for Excessive Alcohol Drinking and Impulsivity in Adults and is Mediated via a CRF/GABAA Mechanism”, Gondré-Lewis, M.C., Warnock, K.T., Wang, H., June Jr, H.L., Bell, K.A., Rabe, H., Tiruveedhula, V.V.N.P.B., Cook, J., Lüddens, H., Aurelian, L. and June Sr, H.L., 2016. Stress, 19(2), pp.235-247, DOI: 10.3109/10253890.2016.1160280.
454. “5-(8-Ethynyl-6-(Pyridin-2-yl)-4H-benzo[f] imidazo [1,5a] [,4] diazepine-3-yl) oxazole (KRM-II-81) is a Novel Alpha 2,3- Selective Potentiator of GABAA Receptors: Improved Bioavailability Enhances Anticonvulsent Effcacy”, Witkin, J.M.; Methuku, K.R.; McDermott,J.; Cerne,R.; Gleason,S.; Cramer,J.; Jones,T.M.; Catlow,J.; Poe,M.; Li,G.; Arnold,L.A.; Ping,X.; Jin,X.; Hobbs,J.; Smith,J.L.; Schkeryantz,J.; Cook, J.M.; J.Med.Chem, Submitted (2016).
455. “Synthesis and Characterzation of a Novel Anxiolytic GABAA Receptor Ligand that Combines Excellent Metabolic Stability, Pharmacokinetics and Anxiolytic Efficacy”, M.M.Poe; K. Methuku; J. Wikin; J. Schkeryantz; J. Cook et al., J. Med. Chem. Submitted.
456. “Total Synthesis of Macrocarpine D and E via an Enolate-Driven Copper-Mediated Cross-Coupling Process: Replacement of Catalytic Palladium with Copper Iodide”, Rahman, Md. T.; Deschamps, J.; Schwabacher, A.; Cook, J.M.; Org. Lett., 18 (17), pp 4174–4177 (2016). Link
457. “Synthesis of Bisindole Alkaloids from the Apocynaceae which Contain a
Macroline or Sarpagine Unit: A Review”, Rahman, Md. T.; Tiruveedhula, V. V. N. P. B.; Cook, J. M.; Special Issue “Diversity of Alkaloids”, Molecules 201621(11), 1525. Link

2017

Benzodiazepine Ligands with Improved α5 Selectivity and Their Airway Smooth Muscle Relaxant Effect”, Puthenkalam, R.; Treven, M.; Ramerstorfer, J.; Steudle, F.; Scholze, P.; Gallos, G.; Poe, M.M.; Methuku, K.R.; Li, Guanguan; Arnold, L.A.; Seighert, W.; Santrac, Anja.; Savic, M.; Emala, C.; Cook, J.M.; Ernst, M., Mol. Pharmacology, 00,0000-0000 (2017).

Alleviation of Multiple Asthmatic Pathologic Features with Orally Available and Subtype Selective GABAA Receptor Modulators”, Forkuo, G.S.; Nieman, A.N.; Yuan, N.; Kodali, R.; Yu, O.B.; Zahn, N.M.; Jahan, R.;  Li, G.; Stephen, M.R.; Guthrie, M.L.; Poe, M.M.; Hartzler, B.; Harris,T.W.; Yocum, G.T.; Emala, C.; Steeber, D.; Stafford, D.C.; Cook, J.M.; Arnold,  L.A., Molecular Pharmaceutics, 00,0000-0000 (2017), DOI: 10.1021/acs.molpharmaceut.7b00183.

“Abuse-related Effects of Subtype-selective GABAA Receptor Positive Allosteric Modulators in an Assay of Intracranial Self-stimulation in Rats”, Schwienteck, K.L.; Li, G.; Poe, M.M.; Cook, J.M.; Banks, M.L.; Negus, S.S., Psychopharmacology, doi: 10.1007/s00213-017-4615-8 (2017).

“Further Evaluation of the Potential Anxiolytic Activity of Imidazo[1,5a] diazepin Agents Selective for α2/α3- Containing GABA Receptors”, Witkin, J.; Cerne, R.; Wakulchik, M.; Gleason, S,; Jones, T.; Li, G.; Arnold, A.; Li, Jun-Xu; Schkeryantz, J.; Methuku, K.; Cook, J.; Poe, M.M., Biochem. Behav., S0091-3057(17): 30088-6. doi: 10.1016/j.pbb.2017.04.009 (2017).

“Identification of Staphylococcus aureusCellular Pathways Affected by the Stilbenoid Lead Drug SK-03-92 Using a Microarray” Antibiotics 20176(3), 17; Link

“Concise Total Synthesis of (−)-Affinisine Oxindole, (+)-Isoalstonisine, (+)-Alstofoline, (−)-Macrogentine, (+)-Na-Demethylalstonisine, (−)-Alstonoxine A, and (+)-Alstonisine” Stephen, M. R..; Rahman, M. T.; Tituveedhula, VVNPB.; Fonseca, G. O.; Deschamps, J. R.; Cook, J. M., Chem. Eur. J. 201723, 15805. http://onlinelibrary.wiley.com/doi/10.1002/chem.201703572/full/

2018

“Total Synthesis of Sarpagine-Related Bioactive Indole Alkaloids” Rahman, M. T.; Deschamps, J. R.; Imler, G. I.; Cook, J. M., Chem. Eur. J. 201824 (10)2354–2359. https://doi.org/10.1002/chem.201705575

“Design and Synthesis of Novel Deuterated Ligands Functionally Selective for the γ-Aminobutyric Acid Type A Receptor (GABAAR) α6 Subtype with Improved Metabolic Stability and Enhanced Bioavailability” Knutson, D. E. et al., J. Med. Chem. 2018, ASAP, https://pubs.acs.org/doi/10.1021/acs.jmedchem.7b01664

Group Pictures

GROUP PHOTO ARCHIVE (hover cursor over photo for caption) Faculty of the year (2016-2017) award goes to Dr. Cook Dr. Cook receiving the award from Mark. 05-23-2017 Professor Kishi, Professor Cook and Professor Sosnovsky (98 years old) at Lunch March… Read More